The effects of the Lactobacillus casei strain on obesity in children: a pilot study
In: Beneficial MicrobesProbiotics Research Laboratory, Juntendo University Postgraduate School, 3rd floor, 2-9-8 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
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Probiotics Research Laboratory, Juntendo University Postgraduate School, 3rd floor, 2-9-8 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
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There are few data regarding the role of probiotics as a dietary intervention in the management of obesity in children. An open prospective examination was conducted to clarify the effects of Lactobacillus casei strain Shirota (LcS)-containing beverages in obese children. We compared the intestinal microbiota and organic acid levels between 12 obese (average age, 10.8 years; body mass index (BMI) Z score, 2.7±1.7) and 22 control children(average age, 8.5 years; BMI Z score, 0.1±0.7), and pre- and post-intervention in the obese children. The obese group underwent diet and exercise therapy for 6 months and then were given an LcS beverage daily for another 6 months and the body weight and serological markers were monitored. Significant reductions in the faecal concentrations of Bifidobacterium (obese group, 7.9±1.5 vs non-obese group, 9.8±0.5 Log10cells/g; P<0.01) along with a significant decline in the Bacteroides fragilis group, Atopobium cluster and Lactobacillus gasseri subgroup, and acetic acid (obese group, 45.1±16.9 vs non-obese group, 57.9±17.6 μmol/g; P<0.05) were observed in the obese group at baseline. A significant decline in body weight (-2.9±4.6%; P<0.05) and an elevation in the high density lipoprotein cholesterol level (+11.1±17.6%; P<0.05) were observed 6 months after ingestion of the LcS beverage compared to baseline. Furthermore, a significant increase in the faecal concentration of Bifidobacterium (7.0±1.2 before ingestion vs 9.1±1.2 Log10cells/g after ingestion; P<0.01) and an apparent increase in the acetic acid concentration (7.0±1.2 before ingestion vs 9.1±1.2 Log10cells/g after ingestion; P<0.01) were observed 6 months after ingestion. LcS contributed to weight loss while also improving the lipid metabolism in obese children via a significant increase in the faecal Bifidobacterium numbers and the acetic acid concentration.
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| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 598 | 587 | 73 |
| Full Text Views | 16 | 11 | 1 |
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The effects of the Lactobacillus casei strain on obesity in children: a pilot study
In: Beneficial MicrobesProbiotics Research Laboratory, Juntendo University Postgraduate School, 3rd floor, 2-9-8 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Search for other papers by S. Nagata in
Current site
Google Scholar
PubMed
Probiotics Research Laboratory, Juntendo University Postgraduate School, 3rd floor, 2-9-8 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Search for other papers by Y. Chiba in
Current site
Google Scholar
PubMed
Search for other papers by C. Wang in
Current site
Google Scholar
PubMed
Search for other papers by Y. Yamashiro in
Current site
Google Scholar
PubMed
There are few data regarding the role of probiotics as a dietary intervention in the management of obesity in children. An open prospective examination was conducted to clarify the effects of Lactobacillus casei strain Shirota (LcS)-containing beverages in obese children. We compared the intestinal microbiota and organic acid levels between 12 obese (average age, 10.8 years; body mass index (BMI) Z score, 2.7±1.7) and 22 control children(average age, 8.5 years; BMI Z score, 0.1±0.7), and pre- and post-intervention in the obese children. The obese group underwent diet and exercise therapy for 6 months and then were given an LcS beverage daily for another 6 months and the body weight and serological markers were monitored. Significant reductions in the faecal concentrations of Bifidobacterium (obese group, 7.9±1.5 vs non-obese group, 9.8±0.5 Log10cells/g; P<0.01) along with a significant decline in the Bacteroides fragilis group, Atopobium cluster and Lactobacillus gasseri subgroup, and acetic acid (obese group, 45.1±16.9 vs non-obese group, 57.9±17.6 μmol/g; P<0.05) were observed in the obese group at baseline. A significant decline in body weight (-2.9±4.6%; P<0.05) and an elevation in the high density lipoprotein cholesterol level (+11.1±17.6%; P<0.05) were observed 6 months after ingestion of the LcS beverage compared to baseline. Furthermore, a significant increase in the faecal concentration of Bifidobacterium (7.0±1.2 before ingestion vs 9.1±1.2 Log10cells/g after ingestion; P<0.01) and an apparent increase in the acetic acid concentration (7.0±1.2 before ingestion vs 9.1±1.2 Log10cells/g after ingestion; P<0.01) were observed 6 months after ingestion. LcS contributed to weight loss while also improving the lipid metabolism in obese children via a significant increase in the faecal Bifidobacterium numbers and the acetic acid concentration.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 598 | 587 | 73 |
| Full Text Views | 16 | 11 | 1 |
| PDF Views & Downloads | 20 | 12 | 1 |