Probiotics with vitamin C for the prevention of upper respiratory tract symptoms in children aged 3-10 years: randomised controlled trial
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Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, W2 1NY, United Kingdom.
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In a double-blind, randomised, parallel-group, placebo-controlled study, healthy school children aged 3-10 years received a probiotic based supplement daily for 6 months to assess the impact on the incidence and duration of upper respiratory tract infection (URTI) symptoms. The intervention comprised Lab4 probiotic (Lactobacillus acidophilus CUL21 and CUL60, Bifidobacterium bifidum CUL20 and Bifidobacterium animalis subsp. lactis CUL34) at 12.5 billion cfu/day plus 50 mg vitamin C or a matching placebo. 171 children were included in the analysis (85 in placebo and 86 in active group). Incidence of coughing was 16% (P=0.0300) significantly lower in the children receiving the active intervention compared to the placebo. No significant differences in the incidence rate of other URTI symptoms were observed. There was significantly lower risk of experiencing five different URTI related symptoms in one day favouring the active group (Risk ratio: 0.31, 95% confidence interval: 0.12, 0.81, P=0.0163). Absenteeism from school and the use of antibiotics was also significantly reduced for those in the active group (-16%, P=0.0060 and -27%, P=0.0203, respectively). Our findings indicate that six months daily supplementation with the Lab4 probiotic and vitamin C combination reduces the incidence of coughing, absenteeism and antibiotic usage in 3 to 10 year old children.
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Angurana, S.K. and Bansal, A., 2020. Probiotics and COVID-19: think about the link. British Journal of Nutrition: 1-26. https://doi.org/10.1017/S000711452000361X
-
Arango Duque, G. and Descoteaux, A., 2014. Macrophage cytokines: involvement in immunity and infectious diseases. Frontiers in Immunology 5: 491. https://doi.org/10.3389/fimmu.2014.00491
-
Baud, D., Dimopoulou Agri, V., Gibson, G.R., Reid, G. and Giannoni, E., 2020. Using probiotics to flatten the curve of coronavirus disease COVID-2019 pandemic. Front Public Health 8: 186. https://doi.org/10.3389/fpubh.2020.00186
-
Carr, A.C. and Maggini, S., 2017. Vitamin C and immune function. Nutrients 9. https://doi.org/10.3390/nu9111211
-
Cohen, H.A., Varsano, I., Kahan, E., Sarrell, E.M. and Uziel, Y., 2004. Effectiveness of an herbal preparation containing echinacea, propolis, and vitamin C in preventing respiratory tract infections in children: a randomized, double-blind, placebo-controlled, multicenter study. Archives of Pediatrics and Adolescent Medicine 158: 217-221. https://doi.org/10.1001/archpedi.158.3.217
-
Colunga Biancatelli, R.M.L., Berrill, M. and Marik, P.E., 2020. The antiviral properties of vitamin C. Expert Review of Anti-Infective Therapy 18: 99-101. https://doi.org/10.1080/14787210.2020.1706483
-
d’Ettorre, G., Ceccarelli, G., Marazzato, M., Campagna, G., Pinacchio, C., Alessandri, F., Ruberto, F., Rossi, G., Celani, L., Scagnolari, C., Mastropietro, C., Trinchieri, V., Recchia, G.E., Mauro, V., Antonelli, G., Pugliese, F. and Mastroianni, C.M., 2020. Challenges in the management of SARS-CoV2 infection: the role of oral bacteriotherapy as complementary therapeutic strategy to avoid the progression of COVID-19. Frontiers in Medicine 7: 389. https://doi.org/10.3389/fmed.2020.00389
-
Davies, T., Plummer, S., Jack, A., Allen, M. and Michael, D., 2018. Lactobacillus and Bifidobacterium promote antibacterial and antiviral immune response in human macrophages. Journal of Probiotics and Health 6: 195. https://doi.org/0.4172/2329-8901.1000195
-
Emre, I.E., Eroglu, Y., Kara, A., Dinleyici, E.C. and Ozen, M., 2020. The effect of probiotics on prevention of upper respiratory tract infections in the paediatric community – a systematic review. Beneficial Microbes 11: 201-211. https://doi.org/10.3920/BM2019.0119
-
Feleszko, W., Marengo, R., Vieira, A.S., Ratajczak, K. and Mayorga Butron, J.L., 2019. Immunity-targeted approaches to the management of chronic and recurrent upper respiratory tract disorders in children. Clinical Otolaryngology 44: 502-510. https://doi.org/10.1111/coa.13335
-
Garaiova, I., Muchová, J., Nagyová, Z., Wang, D., Li, J.V., Országhová, Z., Michael, D.R., Plummer, S.F. and Ďuračková, Z., 2015. Probiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool: a randomised controlled pilot study. European Journal of Clinical Nutrition 69: 373-379. https://doi.org/10.1038/ejcn.2014.174
-
Guo, Y., Cao, W. and Zhu, Y., 2019. Immunoregulatory functions of the IL-12 family of cytokines in antiviral systems. Viruses 11: 772. https://doi.org/10.3390/v11090772
-
Hao, Q., Dong, B.R. and Wu, T., 2015. Probiotics for preventing acute upper respiratory tract infections. Cochrane Database of Systematic Reviews: CD006895. https://doi.org/10.1002/14651858.CD006895.pub3
-
Hatakka, K., Savilahti, E., Pönkä, A., Meurman, J.H., Poussa, T., Näse, L., Saxelin, M. and Korpela, R., 2001. Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial. BMJ 322: 1327.
'Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial ' () 322 BMJ : 1327.
-
Hemilä, H. and Chalker, E., 2013. Vitamin C for preventing and treating the common cold. Cochrane Database of Systematic Reviews 1: CD000980. https://doi.org/10.1002/14651858.CD000980.pub4
-
Hojsak, I., Snovak, N., Abdović, S., Szajewska, H., Misak, Z. and Kolacek, S., 2010. Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: a randomized, double-blind, placebo-controlled trial. Clinical Nutrition 29: 312-316. https://doi.org/10.1016/j.clnu.2009.09.008
-
Holstiege, J., Schink, T., Molokhia, M., Mazzaglia, G., Innocenti, F., Oteri, A., Bezemer, I., Poluzzi, E., Puccini, A., Ulrichsen, S.P., Sturkenboom, M.C., Trifiro, G. and Garbe, E., 2014. Systemic antibiotic prescribing to paediatric outpatients in 5 European countries: a population-based cohort study. BMC Pediatrics 14: 174. https://doi.org/10.1186/1471-2431-14-174
-
Jurca, M., Ramette, A., Dogaru, C.M., Goutaki, M., Spycher, B.D., Latzin, P., Gaillard, E.A. and Kuehni, C.E., 2017. Prevalence of cough throughout childhood: a cohort study. PLoS ONE 12: e0177485. https://doi.org/10.1371/journal.pone.0177485
-
King, S., Glanville, J., Sanders, M.E., Fitzgerald, A. and Varley, D., 2014. Effectiveness of probiotics on the duration of illness in healthy children and adults who develop common acute respiratory infectious conditions: a systematic review and meta-analysis. British Journal of Nutrition 112: 41-54. https://doi.org/10.1017/S0007114514000075
-
King, S., Tancredi, D., Lenoir-Wijnkoop, I., Gould, K., Vann, H., Connors, G., Sanders, M.E., Linder, J.A., Shane, A.L. and Merenstein, D., 2019. Does probiotic consumption reduce antibiotic utilization for common acute infections? A systematic review and meta-analysis. European Journal of Public Health 29: 494-499. https://doi.org/10.1093/eurpub/cky185
-
Laursen, R.P., Larnkjaer, A., Ritz, C., Hauger, H., Michaelsen, K.F. and Molgaard, C., 2017. Probiotics and child care absence due to infections: a randomized controlled trial. Pediatrics 140: e20170735. https://doi.org/10.1542/peds.2017-0735
-
Lazou Ahren, I., Berggren, A., Teixeira, C., Martinsson Niskanen, T. and Larsson, N., 2020. Evaluation of the efficacy of Lactobacillus plantarum HEAL9 and Lactobacillus paracasei 8700:2 on aspects of common cold infections in children attending day care: a randomised, double-blind, placebo-controlled clinical study. European Journal of Nutrition 59: 409-417. https://doi.org/10.1007/s00394-019-02137-8
-
Lenoir-Wijnkoop, I., Merenstein, D., Korchagina, D., Broholm, C., Sanders, M.E. and Tancredi, D., 2019. Probiotics reduce health care cost and societal impact of flu-like respiratory tract infections in the USA: an economic modeling study. Frontiers in Pharmacology 10: 980. https://doi.org/10.3389/fphar.2019.00980
-
Leyer, G.J., Li, S., Mubasher, M.E., Reifer, C. and Ouwehand, A.C., 2009. Probiotic effects on cold and influenza-like symptom incidence and duration in children. Pediatrics 124: e172-e179. https://doi.org/10.1542/peds.2008-2666
-
Maldonado Galdeano, C., Cazorla, S.I., Lemme Dumit, J.M., Velez, E. and Perdigon, G., 2019. Beneficial effects of probiotic consumption on the immune system. annals of nutrition and metabolism 74: 115-124. https://doi.org/10.1159/000496426
-
Marengo, R.L., Ciceran, A. and Del Río Navarro, B.E, 2017. Upper respiratory tract infections in children and adults: burden and management. A narrative summary of selected presentations that took place on 11th-12th May 2017, as part of the Encuentro Latinoamericano de Infecciones Respiratorias Recurrentes (ELAIR) educational event in Mexico City, Mexico. EMJ Respiratory 5: 22-28.
'Upper respiratory tract infections in children and adults: burden and management ' () 5 EMJ Respiratory : 22 -28.
-
Miettinen, M., Pietila, T.E., Kekkonen, R.A., Kankainen, M., Latvala, S., Pirhonen, J., Osterlund, P., Korpela, R. and Julkunen, I., 2012. Nonpathogenic Lactobacillus rhamnosus activates the inflammasome and antiviral responses in human macrophages. Gut Microbes 3: 510-522. https://doi.org/10.4161/gmic.21736
-
Rathinam, V.A. and Fitzgerald, K.A., 2010. Inflammasomes and anti-viral immunity. Journal of Clinical Immunology 30: 632-637. https://doi.org/10.1007/s10875-010-9431-4
-
Rerksuppaphol, S. and Rerksuppaphol, L., 2012. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatrics International 54: 682-687. https://doi.org/10.1111/j.1442-200X.2012.03647.x
-
Tiwari, S.K., Dicks, L.M.T., Popov, I.V., Karaseva, A., Ermakov, A.M., Suvorov, A., Tagg, J.R., Weeks, R. and Chikindas, M.L., 2020. Probiotics at war against viruses: what is missing from the picture? Frontiers in Microbiology 11: 1877. https://doi.org/10.3389/fmicb.2020.01877
-
Vorilhon, P., Arpajou, B., Vaillant Roussel, H., Merlin, E., Pereira, B. and Cabaillot, A., 2019. Efficacy of vitamin C for the prevention and treatment of upper respiratory tract infection. A meta-analysis in children. European Journal of Clinical Pharmacology 75: 303-311. https://doi.org/10.1007/s00228-018-2601-7
-
Zheng, D., Liwinski, T. and Elinav, E., 2020. Interaction between microbiota and immunity in health and disease. Cell Research 30: 492-506. https://doi.org/10.1038/s41422-020-0332-7
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Probiotics with vitamin C for the prevention of upper respiratory tract symptoms in children aged 3-10 years: randomised controlled trial
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Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, W2 1NY, United Kingdom.
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In a double-blind, randomised, parallel-group, placebo-controlled study, healthy school children aged 3-10 years received a probiotic based supplement daily for 6 months to assess the impact on the incidence and duration of upper respiratory tract infection (URTI) symptoms. The intervention comprised Lab4 probiotic (Lactobacillus acidophilus CUL21 and CUL60, Bifidobacterium bifidum CUL20 and Bifidobacterium animalis subsp. lactis CUL34) at 12.5 billion cfu/day plus 50 mg vitamin C or a matching placebo. 171 children were included in the analysis (85 in placebo and 86 in active group). Incidence of coughing was 16% (P=0.0300) significantly lower in the children receiving the active intervention compared to the placebo. No significant differences in the incidence rate of other URTI symptoms were observed. There was significantly lower risk of experiencing five different URTI related symptoms in one day favouring the active group (Risk ratio: 0.31, 95% confidence interval: 0.12, 0.81, P=0.0163). Absenteeism from school and the use of antibiotics was also significantly reduced for those in the active group (-16%, P=0.0060 and -27%, P=0.0203, respectively). Our findings indicate that six months daily supplementation with the Lab4 probiotic and vitamin C combination reduces the incidence of coughing, absenteeism and antibiotic usage in 3 to 10 year old children.
| All Time | Past 365 days | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 0 | 0 | 0 |
| Full Text Views | 786 | 751 | 67 |
| PDF Views & Downloads | 719 | 703 | 52 |